The applications and properties of Ubenimex

Name  Ubenimex Synonyms:  Bestatin; [S-(R*,S*)]-N-(3-Amino-2-hydroxy-1-oxo-4-phenylbuty1)-L-leucine 
Molecular Formula  C16H24N2O4
Molecular Weight  308.38
CAS  Number  58970-76-6
EINECS  261-529-2
Melting point  245 ºC

Ubenimex  is also known as bestatin, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.

Ubenimex  is an antitumor agent effective against murine syngeneic tumors including mouse colon 26 and C1498 leukemia. It was active against MNNG-induced rat tumor by oral administration. Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform.

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